Efficient detection of 1H, 15N correlations in hydrogen bonded low molecular catalyst–substrate intermediates without selective 15N-labelling

Abstract

To date, SOFAST approaches have generally been limited to biomolecules. We present the applicability of SOFAST-HMQC techniques to small molecules in the slow-tumbling regime offering a time-efficient characterization of catalyst substrate hydrogen bonds with nitrogen at natural abundance. This extends NMR access to a broader range of catalyst substrate combinations.