Hyper-reactivity of CD8+ T cells and high expression of IL-3 correlates with occurrence and severity of Long-COVID

URN to cite this document:: urn:nbn:de:bvb:355-epub-766162
DOI to cite this document:: 10.5283/epub.76616

Renner, Kerstin ; Stauffenberg, Franz ; Paulus, Moritz ; Neumayer, Sophia ; Winter-Köhler, Frederike ; Buchtler, Simone ; Schmalenberger, Daniel ; Blaas, Stefan ; Mohr, Arno ; Pfeifer, Michael ; Malfertheiner, Maximilian V. ; Loew, Thomas ; Sester, Martina ; Bals, Robert ; Peterhoff, David

; Schmidt, Barbara

; Mack, Matthias

License: Creative Commons Attribution Non-commercial No Derivatives 4.0
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Date of publication of this fulltext: 29 Apr 2025 05:31

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Abstract

Following SARS-CoV-2 infection, some individuals develop Long-COVID-syndrome lasting for more than 3 months. We analyzed blood samples from patients with Long-COVID, controls without persistent symptoms following SARS-CoV-2-infection and non-infected donors without a history of infection. Long-COVID patients showed clear signs of T cell hyper-activation predominantly in the CD8+ T cell subset ...