Sphingosine 1-phosphate receptor 1signaling in macrophages reduces atherosclerosis in LDL receptor–deficient mice

URN to cite this document:: urn:nbn:de:bvb:355-epub-767567
DOI to cite this document:: 10.5283/epub.76756

Potì, Francesco ; Scalera, Enrica ; Feuerborn, Renata ; Fischer, Josephine ; Arndt, Lilli ; Varga, Georg ; Pardali, Evangelia ; Seidl, Matthias D. ; Fobker, Manfred ; Liebisch, Gerhard ; Hesse, Bettina ; Lukasz, Alexander H. ; Rossaint, Jan ; Kehrel, Beate E. ; Rosenbauer, Frank ; Renné, Thomas ; Christoffersen, Christina ; Simoni, Manuela ; Burkhardt, Ralph ; Nofer, Jerzy-Roch

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Date of publication of this fulltext: 28 May 2025 10:51

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Abstract

Sphingosine 1-phosphate (S1P) is a lysosphingolipid with antiatherogenic properties, but mechanisms underlying its effects remain unclear. We here investigated atherosclerosis development in cholesterol-rich diet–fed LDL receptor–deficient mice with high or low overexpression levels of S1P receptor 1 (S1P1) in macrophages. S1P1-overexpressing macrophages showed increased activity of transcription ...