The Mechanosensitive PIEZO1 Channel Contributes to the Reaction of RAW264.7 Macrophages to Mechanical Strain

URN to cite this document:: urn:nbn:de:bvb:355-epub-767623
DOI to cite this document:: 10.5283/epub.76762

Schröder, Agnes

; Engelhardt, Hanna ; Nogueira, Andressa ; Clausen, Björn ; Kirschneck, Christian ; Jantsch, Jonathan ; Proff, Peter

; Renner, Kathrin ; Paddenberg-Schubert, Eva

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 04 Jun 2025 05:52

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Abstract

The mechanosensitive channel ‘piezo type mechanosensitive ion channel component 1’ (PIEZO1) plays a regulatory role in the response of periodontal ligament fibroblasts (PDLFs) to the mechanical strain that occurs during orthodontic tooth movement. In addition to PDLFs, immune cells such as macrophages are also exposed to mechanical stimuli. Macrophages respond to mechanical strain with increased ...