Blocking MAdCAM-1 in vivo reduces leukocyte extravasation and reverses chronic inflammation in experimental colitis

DOI to cite this document:: 10.5283/epub.770

Farkas, Stefan ; Hornung, Matthias ; Sattler, Christine ; Edtinger, Karoline ; Steinbauer, Markus ; Anthuber, Matthias ; Schlitt, Hans J. ; Herfarth, Hans ; Geissler, Edward K.

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Date of publication of this fulltext: 05 Aug 2009 13:23

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Abstract

Background: Leukocyte recruitment to sites of intestinal inflammation is a crucial multi-step process, leading ultimately to the accumulation of cells in the inflamed tissue. These interactions in the gut are critically dependent on the mucosal addressin cell adhesion molecule-1 (MAdCAM-1), which is expressed on endothelial cells within the mesenteric lymph nodes and the lamina propria of the ...