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Biomechanical aspects of axonal damage in glaucoma: A brief review

Stowell, Cheri ; Burgoyne, Claude F. ; Tamm, Ernst R. ; Ethier, C. Ross ; Dowling, John E. ; Downs, Crawford ; Ellisman, Mark H. ; Fisher, Steven ; Fortune, Brad ; Fruttiger, Marcus ; Jakobs, Tatjana ; Lewis, Geoffrey ; Masland, Richard H. ; Mitchell, Claire H. ; Morrison, John ; Sharma, Sansar C. ; Sigal, Ian ; Sofroniew, Michael ; Wang, Lin ; Wiggs, Janey ; Wu, Samuel



Abstract

The biomechanical environment within the optic nerve head (ONH) is complex and is likely directly involved in the loss of retinal ganglion cells (RGCs) in glaucoma. Unfortunately, our understanding of this process is poor. Here we describe factors that influence ONH biomechanics, including ONH connective tissue microarchitecture and anatomy; intraocular pressure (IOP); and cerebrospinal fluid ...

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