Anti-TNF antibody treatment improves glucocorticoid induced insulin-like growth factor 1 (IGF1) resistance without influencing myoglobin and IGF1 binding proteins 1 and 3

DOI to cite this document:: 10.5283/epub.773

Sarzi-Puttini, P.

; Atzeni, F. ; Schölmerich, J. ; Cutolo, M. ; Straub, R. H.

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Date of publication of this fulltext: 05 Aug 2009 13:24

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Abstract

Background: Insulin-like growth factor 1 (IGF1) is an important determinant of muscle mass because it promotes growth and suppresses protein degradation. IGF1 is decreased in rheumatoid arthritis and juvenile idiopathic arthritis because its synthesis is inhibited by inflammation. In parallel, glucocorticoids induce IGF1 resistance and add to muscle degradation. Objective: To investigate the ...