This article presents and discusses recent information about new advances in morphologic glaucoma research. Recent publications indicate that patients with pseudoexfoliation syndrome might have a similar fibrillopathy in extraocular tissues. Cell cultures of iris tissue from human eyes with pseudoexfoliation syndrome were shown to synthesize pseudoexfoliative material. No new relevant studies dealing with morphologic changes in the trabecular meshwork of eyes with primary open-angle glaucoma have been published. However, the composition of the extracellular matrix in the trabecular meshwork of normal aging human eyes was further clarified with ultraimmunohistochemical methods. The distribution of collagen type VIII in the human eye was examined for the first time. Furthermore, various aspects of the cell biology of the trabecular meshwork were investigated. Experiments on the phagocytic ability of human trabecular cells were performed using perfusion organ cultures. A number of studies showed contractile properties for bovine trabecular meshwork cells, but the significance of these findings for human eyes has yet to be confirmed. Using cationized ferritin as a tracer, researchers demonstrated paracellular routes through the endothelium of the inner wall of Schlemm's canal. Studies of the extracellular matrix of the optic nerve head in glaucomatous human and monkey eyes found collagen changes that might be related to increased intraocular pressure.