A second photoactivatable state of the anion-conducting channelrhodopsin GtACR1 empowers persistent activity

URN to cite this document:: urn:nbn:de:bvb:355-epub-775790
DOI to cite this document:: 10.5283/epub.77579

Labudda, Kristin ; Norahan, Mohamad Javad ; Hübner, Lisa-Marie ; Althoff, Philipp ; Gerwert, Klaus ; Lübben, Mathias

; Rudack, Till

; Kötting, Carsten

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 02 Sep 2025 09:27

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Abstract

Optogenetics is a method to regulate cells, tissues and organisms using light. It is applied to study neurons and to develop diagnostic and therapeutic tools for neuron-related diseases. The cation-conducting channelrhodopsin ChR2 triggers photoinduced depolarization of neuronal cells but generates lower ion currents due to the syn-pathway of its branched photocycle. In contrast, the homologous ...