A Second Photoactivatable State of the Anion-conducting channelrhodopsin GtACR1 empowers persistent activity

URN to cite this document:: urn:nbn:de:bvb:355-epub-771651
DOI to cite this document:: 10.5283/epub.77165

Kötting, Carsten ; Labudda, Kristin ; Norahan, Mohamad ; Hübner, Lisa-Marie ; Althoff, Philipp ; Gerwert, Klaus ; Lübben, Mathias

; Rudack, Till

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Date of publication of this fulltext: 16 Jul 2025 13:56

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Abstract

Optogenetics is a method to regulate cells using light. It is applied to study neurons and to develop diagnostic and therapeutic tools for neuron-related diseases. The cation-conducting channelrhodopsin ChR2 triggers photoinduced depolarization of neuronal cells but generates very low ion currents due to the syn-pathway of its branched photocycle. In contrast, the homologous anion-conducting ACR1 ...