Seamless monotherapy-combination phase I dose-escalation model-based design

URN to cite this document:: urn:nbn:de:bvb:355-epub-777140
DOI to cite this document:: 10.5283/epub.77714

Daniells, Libby

; Jaki, Thomas

; Dayimu, Alimu

; Demiris, Nikos ; Bristi, Basu ; Symeonides, Stefan

; Mozgunov, Pavel

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 22 Sep 2025 05:09

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Abstract

Phase I dose-escalation studies for a single-agent and combination of anti-cancer agents have explored various model-based designs to guide identification of a maximum tolerated dose and recommended phase II dose. This work describes a parallel approach to dose escalation to expedite identification of maximum tolerated doses both for an anti-cancer agent as monotherapy and in combination with ...