Adaptive enrichment trial designs using joint modelling of longitudinal and time-to-event data

URN to cite this document:: urn:nbn:de:bvb:355-epub-777689
DOI to cite this document:: 10.5283/epub.77768

Burdon, Abigail J. ; Baird, Richard D. ; Jaki, Thomas

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 22 Sep 2025 06:46

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Abstract

Adaptive enrichment allows for pre-defined patient subgroups of interest to be investigated throughout the course of a clinical trial. These designs have gained attention in recent years because of their potential to shorten the trial's duration and identify effective therapies tailored to specific patient groups. We describe enrichment trials which consider long-term time-to-event outcomes but ...