Development of a Liposome-Based Serological Assay for SARS-CoV-2 Variants with Special Emphasis on Coupling Chemistries Required to Maintain Protein Antigenicity

URN to cite this document:: urn:nbn:de:bvb:355-epub-777876
DOI to cite this document:: 10.5283/epub.77787

Streif, Simon

; Neckermann, Patrick

; Hoecherl, Kilian ; Reiner, Christina ; Einhauser, Sebastian

; Konrad, Johannes

; Breunig, Miriam

; Wagner, Ralf

; Baeumner, Antje J.

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 19 Sep 2025 15:58

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Abstract

The conjugation of proteins to the outer membranes of liposomes is a standard procedure used in bioanalytical and drug delivery approaches. Herein, we describe the development of a liposome-based surrogate assay for the quantification of SARS-CoV-2 neutralizing antibodies. Taking into consideration differences in amino acid sequences within the receptor-binding domain (RBD) of SARS-CoV-2 Spike ...