Practical guidance for planning resources required to support publicly-funded adaptive clinical trials

URN to cite this document:: urn:nbn:de:bvb:355-epub-778549
DOI to cite this document:: 10.5283/epub.77854

Wason, James M. S. ; Dimairo, Munyaradzi ; Biggs, Katie ; Bowden, Sarah ; Brown, Julia ; Flight, Laura ; Hall, Jamie ; Jaki, Thomas

; Lowe, Rachel ; Pallmann, Philip ; Pilling, Mark A. ; Snowdon, Claire ; Sydes, Matthew R. ; Villar, Sofía S. ; Weir, Christopher J. ; Wilson, Nina ; Yap, Christina ; Hancock, Helen ; Maier, Rebecca

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Date of publication of this fulltext: 29 Sep 2025 06:43

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Abstract

Adaptive designs are a class of methods for improving efficiency and patient benefit of clinical trials. Although their use has increased in recent years, research suggests they are not used in many situations where they have potential to bring benefit. One barrier to their more widespread use is a lack of understanding about how the choice to use an adaptive design, rather than a traditional ...