Direkt zum Inhalt

Wason, James M. S. ; Dimairo, Munyaradzi ; Biggs, Katie ; Bowden, Sarah ; Brown, Julia ; Flight, Laura ; Hall, Jamie ; Jaki, Thomas ; Lowe, Rachel ; Pallmann, Philip ; Pilling, Mark A. ; Snowdon, Claire ; Sydes, Matthew R. ; Villar, Sofía S. ; Weir, Christopher J. ; Wilson, Nina ; Yap, Christina ; Hancock, Helen ; Maier, Rebecca

Practical guidance for planning resources required to support publicly-funded adaptive clinical trials

Wason, James M. S., Dimairo, Munyaradzi, Biggs, Katie, Bowden, Sarah, Brown, Julia, Flight, Laura, Hall, Jamie, Jaki, Thomas , Lowe, Rachel, Pallmann, Philip, Pilling, Mark A., Snowdon, Claire, Sydes, Matthew R., Villar, Sofía S., Weir, Christopher J., Wilson, Nina, Yap, Christina, Hancock, Helen und Maier, Rebecca (2022) Practical guidance for planning resources required to support publicly-funded adaptive clinical trials. BMC Medicine 20, S. 254.

Veröffentlichungsdatum dieses Volltextes: 29 Sep 2025 06:43
Artikel
DOI zum Zitieren dieses Dokuments: 10.5283/epub.77854


Zusammenfassung

Adaptive designs are a class of methods for improving efficiency and patient benefit of clinical trials. Although their use has increased in recent years, research suggests they are not used in many situations where they have potential to bring benefit. One barrier to their more widespread use is a lack of understanding about how the choice to use an adaptive design, rather than a traditional ...

Adaptive designs are a class of methods for improving efficiency and patient benefit of clinical trials. Although their use has increased in recent years, research suggests they are not used in many situations where they have potential to bring benefit. One barrier to their more widespread use is a lack of understanding about how the choice to use an adaptive design, rather than a traditional design, affects resources (staff and non-staff) required to set-up, conduct and report a trial. The Costing Adaptive Trials project investigated this issue using quantitative and qualitative research amongst UK Clinical Trials Units. Here, we present guidance that is informed by our research, on considering the appropriate resourcing of adaptive trials. We outline a five-step process to estimate the resources required and provide an accompanying costing tool. The process involves understanding the tasks required to undertake a trial, and how the adaptive design affects them. We identify barriers in the publicly funded landscape and provide recommendations to trial funders that would address them. Although our guidance and recommendations are most relevant to UK non-commercial trials, many aspects are relevant more widely.



["render_heading_insitutions" not defined]


Details

DokumentenartArtikel
Titel eines Journals oder einer ZeitschriftBMC Medicine
Verlag:Springer Nature
Band:20
Seitenbereich:S. 254
Datum10 August 2022
InstitutionenInformatik und Data Science > Fachbereich Maschinelles Lernen und Data Science > Chair for Computational Statistics (Prof. Dr. Thomas Jaki)
Identifikationsnummer
WertTyp
10.1186/s12916-022-02445-7DOI
Stichwörter / KeywordsAdaptive designs Adaptive clinical trials Clinical trials Efficiency Resource requirements Trial coordination
Dewey-Dezimal-Klassifikation000 Informatik, Informationswissenschaft, allgemeine Werke > 004 Informatik
StatusVeröffentlicht
BegutachtetJa, diese Version wurde begutachtet
An der Universität Regensburg entstandenNein
URN der UB Regensburgurn:nbn:de:bvb:355-epub-778549
Dokumenten-ID77854

Bibliographische Daten exportieren

Nur für Besitzer und Autoren: Kontrollseite des Eintrags

nach oben