An order restricted multi‐arm multi‐stage clinical trial design

URN to cite this document:: urn:nbn:de:bvb:355-epub-778559
DOI to cite this document:: 10.5283/epub.77855

Serra, Alessandra ; Mozgunov, Pavel ; Jaki, Thomas

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 29 Sep 2025 11:59

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Abstract

One family of designs that can noticeably improve efficiency in later stages of drug development are multi-arm multi-stage (MAMS) designs. They allow several arms to be studied concurrently and gain efficiency by dropping poorly performing treatment arms during the trial as well as by allowing to stop early for benefit. Conventional MAMS designs were developed for the setting, in which treatment ...