A dose‐finding design for dual‐agent trials with patient‐specific doses for one agent with application to an opiate detoxification trial

URN to cite this document:: urn:nbn:de:bvb:355-epub-778589
DOI to cite this document:: 10.5283/epub.77858

Mozgunov, Pavel ; Cro, Suzie ; Lingford‐Hughes, Anne ; Paterson, Louise M. ; Jaki, Thomas

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 30 Sep 2025 05:55

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Abstract

There is a growing interest in early phase dose-finding clinical trials studying combinations of several treatments. While the majority of dose finding designs for such setting were proposed for oncology trials, the corresponding designs are also essential in other therapeutic areas. Furthermore, there is increased recognition of recommending the patient-specific doses/combinations, rather than a ...