A benchmark for dose-finding studies with unknown ordering

URN to cite this document:: urn:nbn:de:bvb:355-epub-778596
DOI to cite this document:: 10.5283/epub.77859

Mozgunov, Pavel ; Paoletti, Xavier ; Jaki, Thomas

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 30 Sep 2025 06:01

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Abstract

An important tool to evaluate the performance of a dose-finding design is the nonparametric optimal benchmark that provides an upper bound on the performance of a design under a given scenario. A fundamental assumption of the benchmark is that the investigator can arrange doses in a monotonically increasing toxicity order. While the benchmark can be still applied to combination studies in which ...