Synthesis of α-Amino Acids by ConPET-Mediated CO2 Fixation into Amides

URN to cite this document:: urn:nbn:de:bvb:355-epub-779854
DOI to cite this document:: 10.5283/epub.77985

Vega, Kimberly Benedetti ; Sánchez, Alejandro Heredero ; Mandal, Tanumoy ; Silva, Wagner

; Gschwind, Ruth M.

; Neto, Attilio Chiavegatti ; Barbosa Ferreira, Marco Antonio ; König, Burkhard

; Paixão, Márcio Weber

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 21 Oct 2025 04:23

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Abstract

Herein, we report a photocatalytic method for the selective functionalization of α-C(sp3)-H bonds adjacent to the nitrogen atom in amides. By harnessing a synergistic combination of hydrogen atom transfer (HAT), consecutive photoinduced electron transfer (ConPET), and reductive radical-polar crossover, we efficiently incorporated high-value electrophiles, including CO2, 13CO2, and deuterium, at ...