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Hadjiiona, Antigoni ; Michaelides, Ioannis ; Kummer, Peter ; Kappelmeyer, Maurice ; Koeninger, A. ; Reuschel, E.

Frequency of CMV testing during pregnancy-a retrospective study

Hadjiiona, Antigoni, Michaelides, Ioannis , Kummer, Peter, Kappelmeyer, Maurice, Koeninger, A. and Reuschel, E. (2025) Frequency of CMV testing during pregnancy-a retrospective study. Archives of Gynecology and Obstetrics 311 (5), pp. 1297-1304.

Date of publication of this fulltext: 23 Oct 2025 13:37
Article
DOI to cite this document: 10.5283/epub.78014


Abstract

Purpose The cytomegalovirus (CMV) belongs to the family of human Herpesviridae and is distributed worldwide. It is the most common cause of viral congenital infections and can have serious consequences for the health of the fetus in the event of a vertical transmission. This study, taking place for the first time in Upper Palatinate, Bavaria, aims to evaluate the frequency of CMV testing among ...

Purpose
The cytomegalovirus (CMV) belongs to the family of human Herpesviridae and is distributed worldwide. It is the most common cause of viral congenital infections and can have serious consequences for the health of the fetus in the event of a vertical transmission. This study, taking place for the first time in Upper Palatinate, Bavaria, aims to evaluate the frequency of CMV testing among pregnant women in our region in Germany, which for some individuals can be an expensive individual health service.

Methods
Retrospectively, 1000 pregnant patients aged 17–45 years who were treated in the University Clinic St. Hedwig, Regensburg, Germany, were included in the study. It was investigated whether a CMV test was carried out during pregnancy and which results were obtained.

Results
597 patients (59.7%) had not received a CMV test during pregnancy. Among the 403 (40.3%) patients who had undergone CMV testing, seropositivity was detected in 143 (35.5%). 257 patients (63.8%) were seronegative, while 3 (0.74%) had a primary infection.

Conclusion
Although CMV is the most common pathogen of viral congenital infections and can severely impair the health of affected newborns, CMV diagnostics during pregnancy is still not an integral part of the maternity guidelines in Germany,
but rather an individual healthcare service, meaning that the patients undergoing the test must bear the full cost. An antiviral treatment with valacyclovir has shown good preventive and therapeutic success, but unfortunately, there is currently no vaccination available to prevent vertical transmission, which is why early diagnosis and hygiene measures are the most
important means of preventing seroconversion of the mother and possible infection of the fetus.



Involved Institutions


Details

Item typeArticle
Journal or Publication TitleArchives of Gynecology and Obstetrics
Publisher:Springer
Open Access Type:DEAL (Springer Gold)
Volume:311
Number of Issue or Book Chapter:5
Page Range:pp. 1297-1304
Date31 January 2025
InstitutionsMedicine > Lehrstuhl für Frauenheilkunde und Geburtshilfe (Schwerpunkt Frauenheilkunde)
Identification Number
ValueType
10.1007/s00404-025-07962-3DOI
KeywordsCytomegalovirus · Prenatal care · Congenital infection · Pregnancy
Dewey Decimal Classification600 Technology > 610 Medical sciences Medicine
StatusPublished
RefereedYes, this version has been refereed
Created at the University of RegensburgYes
URN of the UB Regensburgurn:nbn:de:bvb:355-epub-780142
Item ID78014

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