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Is histological grade a useful parameter in muscle-invasive urothelial bladder cancer? Results from a multicenter study on the impact of different grading systems on disease-free survival after upfront radical cystectomy

URN to cite this document:
urn:nbn:de:bvb:355-epub-781954
DOI to cite this document:
10.5283/epub.78195
Rinderknecht, Emily ; Claps, Francesco ; Bostrom, Peter J. ; Shariat, Shahrokh F. ; Neuzillet, Yann ; Zlotta, Alexandre R. ; Trombetta, Carlo ; Eckstein, Markus ; Lijnen, Renee A. G. ; Mertens, Laura S. ; Bussani, Rossana ; Burger, Maximilian ; van Leenders, Geert J. L. H. ; Boormans, Joost L. ; Wullich, Bernd ; Hartmann, Arndt ; Pavan, Nicola ; Pouessel, Damien ; van der Kwast, Theo H. ; Allory, Yves ; Zuiverloon, Tahlita C. M. ; Lotan, Yair ; van Rhijn, Bas W. G. ; Mayr, Roman
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Date of publication of this fulltext: 25 Nov 2025 05:13

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Abstract

Purpose The prognostic value of histopathological grade in muscle-invasive urothelial carcinoma (MIBC) to predict disease-specific survival (DSS) is understudied. While grading systems like WHO1973 and WHO2004 are established in non-muscle-invasive bladder cancer (NMIBC), their relevance in MIBC remains controversial. This study assessed the prognostic impact of histopathological grade on DSS in ...

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