SARS‐CoV‐2 nucleocapsid protein variants have differential RNA chaperone activity

URN to cite this document:: urn:nbn:de:bvb:355-epub-781963
DOI to cite this document:: 10.5283/epub.78196

Babl, Sabrina ; Seidel, Julia M. ; Kugler, Fabian

; Silberhorn, Elisabeth ; Ludwig, Anna ; Abel, Jonas ; Winklbauer, Sophia ; Schaub, Niklas ; Materna‐Reichelt, Silvia ; Honarnejad, Kamran ; Stojanović Gužvić, Nataša ; Längst, Gernot

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Date of publication of this fulltext: 25 Nov 2025 05:24

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Abstract

The single-stranded RNA genome of the SARS-CoV-2 virus is characterized by a complex secondary structure formed by patches of intramolecular RNA double-strands. Here, we show that the nucleocapsid (N) protein is not only the specific viral RNA packaging protein, but also acts as an RNA chaperone, facilitating RNA folding. RNA chaperones are classified by their non-specific RNA binding and the ...