Inhibition of protein kinase C activity enables mineralization of senescent dental follicle cells with almost no osteogenic differentiation potential

URN to cite this document:: urn:nbn:de:bvb:355-epub-782992
DOI to cite this document:: 10.5283/epub.78299

Morsczeck, Christian

; Reck, Anja ; De Pellegrin, Michela ; Reichert, Torsten E.

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 09 Dec 2025 05:31

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Abstract

Objective Dental follicle cell lines with a senescence phenotype have a poor differentiation potential into biomineralizing cells. Previous studies have shown that protein kinase C (PKC) and protein kinase B (AKT) regulate the differentiation of DFCs. This study investigates the extent to which regulation of PKC and AKT can improve the differentiation of dental follicle cells with poor ...