On the Origin of Substrate Specificity of Enzymes from the Amidohydrolase Superfamily

URN to cite this document:: urn:nbn:de:bvb:355-epub-783018
DOI to cite this document:: 10.5283/epub.78301

Drexler, Lukas ; Fürtges, Torben F. ; Rudack, Till

; Sterner, Reinhard

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Date of publication of this fulltext: 09 Dec 2025 05:53

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Abstract

The sequencing of numerous genomes has led to the identification of open reading frames for millions of enzymes, many of which use unknown substrates. Hence, the identification of both primary and promiscuous activities remains a major challenge for enzyme research. Here, we identified the mechanistic basis of substrate specificity for members of the amidohydrolase superfamily (AHS). ...