United European Gastroenterology (UEG) has launched an initiative to promote physician well-being and prevent burnout. This current concept article is based on a survey of the National Societies Forum and National Societies Committee, a meta-analysis by Shiha et al., and a scoping review of evidence-based interventions. It identifies key systemic and individual drivers of burnout, outlines its consequences, and presents strategies for intervention—recognising that physician burnout threatens individual health, patient safety, and the sustainability of health care systems. Burnout in gastroenterology is driven by demanding workloads, complex procedures, and increasing administrative tasks. Addressing physician well-being must be viewed as a systemic challenge requiring coordinated efforts from individuals, hospitals, and scientific societies. National and specialist GI societies are pivotal. They must implement initiatives and advocate for systemic change through education, policy advocacy, and sustainable work design. Acknowledgement of burnout is a start. Progress requires commitment to well-being and continuing research.