Effect of Ropivacain and Bupivacain on Calcium‐Related and G‐Protein Coupled Processes in PMNs: A Human In‐Vitro Study

URN to cite this document:: urn:nbn:de:bvb:355-epub-783141
DOI to cite this document:: 10.5283/epub.78314

Kraus, Richard Felix

; Galla, Thies ; Gruber, Michael

; Wittmann, Sigrid

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 10 Dec 2025 12:47

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Abstract

Background and Aims: We investigated the impact of altered intracellular calcium levels and G-protein-coupled receptor (GPCRs) signaling inhibition on migration and NETosis of polymorphonuclear leukocytes (PMNs) under influence of bupivacaine and ropivacaine. Methods: PMNs were isolated from whole blood of healthy volunteers by centrifugation. In vitro µSlide chemotaxis assays were ...