Perioperative Piperacillin/Tazobactam Reduces Early Onset SSI in Preirradiated Patients Undergoing Microvascular Head and Neck Reconstruction

URN to cite this document:: urn:nbn:de:bvb:355-epub-784086
DOI to cite this document:: 10.5283/epub.78408

Schuderer, Johannes G.

; Hoferer, Florian ; Eichberger, Jonas ; Fiedler, Mathias

; Gessner, André

; Bauernfeind, Stilla

; Gottsauner, Maximilian ; Nieberle, Felix

; Maurer, Michael

; Meier, Johannes K. ; Reichert, Torsten E. ; Ettl, Tobias

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 09 Jan 2026 07:57

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Abstract

Background Preirradiated patients undergoing microvascular head and neck reconstruction for tumor recurrence or osteoradionecrosis (ORN) face surgical site infection (SSI) rates exceeding 30%. The impact of perioperative extended-spectrum antibiotic coverage remains unclear. This study hypothesizes that calculated prophylaxis with piperacillin/tazobactam reduces early-onset SSI in this ...