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Eder, Christina ; Gerling, Stephan ; Brandstetter, Susanne ; Dechant, Markus-Johann ; Köninger, Angela ; Schnabel, Annegret ; Apfelbacher, Christian J. ; Wellmann, Sven ; Kabesch, Michael ; Ambrosch, Andreas ; Arndt, Petra A. ; Baessler, Andrea ; Berneburg, Mark ; Brunner, Romuald ; Malfertheiner, Sara Fill ; Franke, André ; Häsler, Robert ; Heid, Iris M. ; Heinze, Stefanie ; Högler, Wolfgang ; Kerzel, Sebastian ; Koller, Michael ; Leitzmann, Michael ; Lennon, Áine M. ; Rothfuß, David ; Promm, Martin ; Schaub, Bianca ; Weidinger, Stephan ; Michel, Holger

Influence of mode of delivery on neonatal QTc

Article

Eder, Christina, Gerling, Stephan , Brandstetter, Susanne , Dechant, Markus-Johann, Köninger, Angela, Schnabel, Annegret, Apfelbacher, Christian J. , Wellmann, Sven , Kabesch, Michael , Ambrosch, Andreas, Arndt, Petra A., Baessler, Andrea, Berneburg, Mark , Brunner, Romuald , Malfertheiner, Sara Fill , Franke, André, Häsler, Robert, Heid, Iris M., Heinze, Stefanie, Högler, Wolfgang, Kerzel, Sebastian , Koller, Michael , Leitzmann, Michael , Lennon, Áine M. , Rothfuß, David, Promm, Martin, Schaub, Bianca, Weidinger, Stephan and Michel, Holger (2026) Influence of mode of delivery on neonatal QTc. Journal of Perinatology.

DOI to cite this document: 10.5283/epub.78987


Abstract

Objective: To evaluate the influence of mode of delivery on repolarisation and QT interval in the neonatal electrocardiogram (ECG). Study design: KUNO-Kids is a prospective, population-based birth cohort study. Neonates received an ECG within the first week of life; subgroups were divided according to mode of delivery. Effects on neonatal QT interval were tested by linear and logistic ...

Objective:
To evaluate the influence of mode of delivery on repolarisation and QT interval in the neonatal electrocardiogram (ECG).

Study design:
KUNO-Kids is a prospective, population-based birth cohort study. Neonates received an ECG within the first week of life; subgroups were divided according to mode of delivery. Effects on neonatal QT interval were tested by linear and logistic regression analyses, adjusting for age at ECG recording.

Results:
In total, 712 neonates were included. The primary caesarean section group showed a significant higher mean QTc (regression coefficient 6.03, p = 0.033) and a significantly increased rate of prolonged QTc >450 ms (odds ratio 2.4, p = 0.042), compared to the spontaneous delivery group.

Conclusion:
The mode of delivery has a significant effect on neonatal QTc. Clinicians should consider this influence when deciding on postnatal and follow-up examinations, regarding additional risk factors for acquired long QT interval.



Involved Institutions


Details

Item typeArticle
Journal or Publication TitleJournal of Perinatology
PublisherSpringer
Open Access TypeDEAL (Springer)
Date16 March 2026
Date of publication19 Mar 2026 11:36
InstitutionsMedicine > Lehrstuhl für Kinder- und Jugendmedizin
Projects
Funded by: Bundesministerium für Bildung und Forschung (BMBF) (01ZX1306E)
Identification Number
ValueType
10.1038/s41372-026-02624-xDOI
KeywordsMedical research; Risk factors
Dewey Decimal Classification600 Technology > 610 Medical sciences Medicine
StatusPublished
RefereedYes, this version has been refereed
Created at the University of RegensburgPartially
URN of the UB Regensburgurn:nbn:de:bvb:355-epub-789876
Item ID78987

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