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Tumor-derived lactic acid modulates dendritic cell activation and antigen expression

Gottfried, Eva, Kunz-Schughart, Leoni A., Ebner, Stephanie, Mueller-Klieser, Wolfgang, Hoves, Sabine, Andreesen, Reinhard, Mackensen, Andreas and Kreutz, Marina (2006) Tumor-derived lactic acid modulates dendritic cell activation and antigen expression. Blood 107 (5), pp. 2013-2021.

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Date of publication of this fulltext: 05 Aug 2009 13:24

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Other URL: http://dx.doi.org/10.1182/blood-2005-05-1795


The tumor milieu can influence dendritic cell (DC) differentiation. We analyzed DC differentiation in a 3-dimensional tumor model and propose a new mechanism of DC modulation by the tumor environment. Monocytes were cultured in the presence of IL-4 and GM-CSF within multicellular tumor spheroids (MCTSs) generated from different tumor cell lines. Monocytes invaded the MCTSs and differentiated into ...


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Item type:Article
Date:1 March 2006
Institutions:Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie)
Identification Number:
16278308PubMed ID
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:791
Owner only: item control page


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