Tumor-derived lactic acid modulates dendritic cell activation and antigen expression

DOI to cite this document:: 10.5283/epub.791

Gottfried, Eva ; Kunz-Schughart, Leoni A. ; Ebner, Stephanie ; Mueller-Klieser, Wolfgang ; Hoves, Sabine

; Andreesen, Reinhard ; Mackensen, Andreas ; Kreutz, Marina

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Date of publication of this fulltext: 05 Aug 2009 13:24

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Abstract

The tumor milieu can influence dendritic cell (DC) differentiation. We analyzed DC differentiation in a 3-dimensional tumor model and propose a new mechanism of DC modulation by the tumor environment. Monocytes were cultured in the presence of IL-4 and GM-CSF within multicellular tumor spheroids (MCTSs) generated from different tumor cell lines. Monocytes invaded the MCTSs and differentiated into ...