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Tenascin-C protein is induced by transforming growth factor-beta1 but does not correlate with time to tumor progression in high-grade gliomas

DOI to cite this document:
Hau, Peter ; Kunz-Schughart, Leoni A. ; Rümmele, Petra ; Arslan, Füsun ; Dörfelt, Anett ; Koch, Horst ; Lohmeier, Annette ; Hirschmann, Birgit ; Müller, Adolf ; Bogdahn, Ulrich ; Bosserhoff, Anja-Katrin
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Date of publication of this fulltext: 05 Aug 2009 13:24


BACKGROUND: Tenascin-C is an extracellular matrix protein known to correlate with prognosis in patients with glioblastoma, probably by stimulation of invasion and neoangiogenesis. Transforming Growth Factor-beta1 (TGF-beta1) plays an important role in the biology of high-grade gliomas, partly by regulating invasion of these tumors into parenchyma. This study was designed to evaluate if TGF-beta1 ...


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