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CD4+CD25+ regulatory T cells and graft-versus-host disease

Hoffmann, Petra and Edinger, Matthias (2006) CD4+CD25+ regulatory T cells and graft-versus-host disease. Seminars in hematology 43 (1), pp. 62-69.

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Other URL: http://dx.doi.org/10.1053/j.seminhematol.2005.09.006


Peripheral suppression of autoreactive T cells by specialized T-cell populations is one of several mechanisms ensuring self-tolerance within the adaptive immune system. Thymus-derived CD4+CD25+ T cells expressing the transcriptional repressor FOXP3 mediate such immunoregulatory functions and are pivotal for the prevention of autoimmunity. As peripheral tolerance induction is a prerequisite for ...


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Item type:Article
Date:January 2006
Institutions:Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie)
Identification Number:
16412790PubMed ID
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:817
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