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Prognostic significance of NOD2/CARD15 variants in HLA-identical sibling hematopoietic stem cell transplantation: effect on long-term outcome is confirmed in 2 independent cohorts and may be modulated by the type of gastrointestinal decontamination

DOI to cite this document:
10.5283/epub.837
Holler, Ernst ; Rogler, Gerhard ; Brenmoehl, Julia ; Hahn, Joachim ; Herfarth, Hans ; Greinix, Hildegard ; Dickinson, Anne M. ; Socié, Gerard ; Wolff, Daniel ; Fischer, Gottfried ; Jackson, Graham ; Rocha, Vanderson ; Steiner, Beate ; Eissner, Günther ; Marienhagen, Joerg ; Schoelmerich, Juergen ; Andreesen, Reinhard
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Date of publication of this fulltext: 05 Aug 2009 13:24


Abstract

To assess the role of NOD2/CARD15 variants on the long-term outcome of allogeneic stem cell transplantation in a genetically homogeneous group, we extended our previous study (cohort I, n = 78) and typed DNA for NOD2/CARD15 single nucleotide polymorphisms (SNPs) from an additional 225 recipients and their HLA-identical sibling donors (cohort II) treated at four other European centers. Results of ...

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