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Study of the in vitro penetration of the topical glucocorticoid betamethasone-17-valerate from solution-type gels into a multilayer membrane system.

URN to cite this document:
Bendas, Barbara ; Göpferich, Achim ; Lee, Geoffrey ; Neubert, R.
Date of publication of this fulltext: 14 Aug 2009 10:24


The in vitro transport of betamethasone-17-valerate (1) into a multilayer membrane system has been investigated. Subsaturated formulations of 1 were studied as formed by mixing appropriate propylene glycol/water cosolvent systems. The AUC (drug concentration in acce ptor membrane as a function of time) and the diffusivity of the drug in the vehicle were used to evaluate the results of the in ...


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