Study of the in vitro penetration of the topical glucocorticoid betamethasone-17-valerate from solution-type gels into a multilayer membrane system.

URN to cite this document:: urn:nbn:de:bvb:355-epub-84885
DOI to cite this document:: 10.5283/epub.8488

Bendas, Barbara ; Göpferich, Achim ; Lee, Geoffrey ; Neubert, R.

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Date of publication of this fulltext: 14 Aug 2009 10:24

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Abstract

The in vitro transport of betamethasone-17-valerate (1) into a multilayer membrane system has been investigated. Subsaturated formulations of 1 were studied as formed by mixing appropriate propylene glycol/water cosolvent systems. The AUC (drug concentration in acce ptor membrane as a function of time) and the diffusivity of the drug in the vehicle were used to evaluate the results of the in ...