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Study of the in vitro penetration of the topical glucocorticoid betamethasone-17-valerate from solution-type gels into a multilayer membrane system.
Bendas, Barbara, Göpferich, Achim, Lee, Geoffrey and Neubert, R. (1993) Study of the in vitro penetration of the topical glucocorticoid betamethasone-17-valerate from solution-type gels into a multilayer membrane system. Die Pharmazie 48 (3), pp. 199-201.Date of publication of this fulltext: 14 Aug 2009 10:24
Article
DOI to cite this document: 10.5283/epub.8488
Abstract
The in vitro transport of betamethasone-17-valerate (1) into a multilayer membrane system has been investigated. Subsaturated formulations of 1 were studied as formed by mixing appropriate propylene glycol/water cosolvent systems. The AUC (drug concentration in acce ptor membrane as a function of time) and the diffusivity of the drug in the vehicle were used to evaluate the results of the in ...
The in vitro transport of betamethasone-17-valerate (1) into a multilayer membrane system has been investigated. Subsaturated formulations of 1 were studied as formed by mixing appropriate propylene glycol/water cosolvent systems. The AUC (drug concentration in acce ptor membrane as a function of time) and the diffusivity of the drug in the vehicle were used to evaluate the results of the in vitro transport. The importance and relationship between solubility, partition coefficient, and diffusivity for the process of in vitro penetration of 1 are discussed.
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| Item type | Article | ||||||||||||||
| Journal or Publication Title | Die Pharmazie | ||||||||||||||
| Volume: | 48 | ||||||||||||||
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| Number of Issue or Book Chapter: | 3 | ||||||||||||||
| Page Range: | pp. 199-201 | ||||||||||||||
| Date | 1993 | ||||||||||||||
| Institutions | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich) | ||||||||||||||
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| Classification |
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| Dewey Decimal Classification | 500 Science > 570 Life sciences 600 Technology > 610 Medical sciences Medicine | ||||||||||||||
| Status | Published | ||||||||||||||
| Refereed | Yes, this version has been refereed | ||||||||||||||
| Created at the University of Regensburg | No | ||||||||||||||
| URN of the UB Regensburg | urn:nbn:de:bvb:355-epub-84885 | ||||||||||||||
| Item ID | 8488 |
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