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Study of the in vitro penetration of the topical glucocorticoid betamethasone-17-valerate from solution-type gels into a multilayer membrane system.
Bendas, Barbara, Göpferich, Achim, Lee, Geoffrey und Neubert, R. (1993) Study of the in vitro penetration of the topical glucocorticoid betamethasone-17-valerate from solution-type gels into a multilayer membrane system. Die Pharmazie 48 (3), S. 199-201.Veröffentlichungsdatum dieses Volltextes: 14 Aug 2009 10:24
Artikel
DOI zum Zitieren dieses Dokuments: 10.5283/epub.8488
Zusammenfassung
The in vitro transport of betamethasone-17-valerate (1) into a multilayer membrane system has been investigated. Subsaturated formulations of 1 were studied as formed by mixing appropriate propylene glycol/water cosolvent systems. The AUC (drug concentration in acce ptor membrane as a function of time) and the diffusivity of the drug in the vehicle were used to evaluate the results of the in ...
The in vitro transport of betamethasone-17-valerate (1) into a multilayer membrane system has been investigated. Subsaturated formulations of 1 were studied as formed by mixing appropriate propylene glycol/water cosolvent systems. The AUC (drug concentration in acce ptor membrane as a function of time) and the diffusivity of the drug in the vehicle were used to evaluate the results of the in vitro transport. The importance and relationship between solubility, partition coefficient, and diffusivity for the process of in vitro penetration of 1 are discussed.
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| Dokumentenart | Artikel | ||||||||||||||
| Titel eines Journals oder einer Zeitschrift | Die Pharmazie | ||||||||||||||
| Band: | 48 | ||||||||||||||
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| Nummer des Zeitschriftenheftes oder des Kapitels: | 3 | ||||||||||||||
| Seitenbereich: | S. 199-201 | ||||||||||||||
| Datum | 1993 | ||||||||||||||
| Institutionen | Chemie und Pharmazie > Institut für Pharmazie > Lehrstuhl Pharmazeutische Technologie (Prof. Göpferich) | ||||||||||||||
| Identifikationsnummer |
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| Klassifikation |
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| Dewey-Dezimal-Klassifikation | 500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin | ||||||||||||||
| Status | Veröffentlicht | ||||||||||||||
| Begutachtet | Ja, diese Version wurde begutachtet | ||||||||||||||
| An der Universität Regensburg entstanden | Nein | ||||||||||||||
| URN der UB Regensburg | urn:nbn:de:bvb:355-epub-84885 | ||||||||||||||
| Dokumenten-ID | 8488 |
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