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Defects in N-glycosylation induce apoptosis in yeast

Hauptmann, Peter, Riel, Constanze, Kunz-Schughart, Leoni A., Fröhlich, Kai-Uwe, Madeo, Frank and Lehle, Ludwig (2006) Defects in N-glycosylation induce apoptosis in yeast. Molecular Microbiology 59 (3), pp. 765-778.

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Date of publication of this fulltext: 05 Aug 2009 13:21

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Other URL: http://www.blackwell-synergy.com/doi/abs/10.1111/j.1365-2958.2005.04981.x


N-glycosylation in the endoplasmic reticulum is an essential protein modification and highly conserved in evolution from yeast to man. Defects of N-glycosylation in humans lead to congenital disorders. The pivotal step of this pathway is the transfer of the evolutionarily conserved lipid-linked core-oligosaccharide to the nascent polypeptide chain, catalysed by the oligosaccharyltransferase. One ...


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Item type:Article
Date:February 2006
Institutions:Biology, Preclinical Medicine > Institut für Pflanzenwissenschaften
Medicine > Lehrstuhl für Pathologie
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Dewey Decimal Classification:500 Science > 580 Botanical sciences
500 Science > 570 Life sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:85
Owner only: item control page


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