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Defects in N-glycosylation induce apoptosis in yeast

DOI to cite this document:
Hauptmann, Peter ; Riel, Constanze ; Kunz-Schughart, Leoni A. ; Fröhlich, Kai-Uwe ; Madeo, Frank ; Lehle, Ludwig
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Date of publication of this fulltext: 05 Aug 2009 13:21


N-glycosylation in the endoplasmic reticulum is an essential protein modification and highly conserved in evolution from yeast to man. Defects of N-glycosylation in humans lead to congenital disorders. The pivotal step of this pathway is the transfer of the evolutionarily conserved lipid-linked core-oligosaccharide to the nascent polypeptide chain, catalysed by the oligosaccharyltransferase. One ...


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