Measurement of drug diffusivity in stratum corneum membranes and a polyacrylate matrix

URN to cite this document:: urn:nbn:de:bvb:355-epub-85072
DOI to cite this document:: 10.5283/epub.8507

Göpferich, Achim ; Lee, Geoffrey

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Date of publication of this fulltext: 05 Aug 2009 13:59

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Item type:	Article
Journal or Publication Title:	International Journal of Pharmaceutics
Publisher:	Elsevier
Volume:	71
Number of Issue or Book Chapter:	3
Page Range:	pp. 245-253
Date:	1991
Institutions:	Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich)
Keywords:	STRATUM-CORNEUM; POLYMER MATRIX; DIFFUSION; MEASUREMENT
Dewey Decimal Classification:	500 Science > 570 Life sciences 600 Technology > 610 Medical sciences Medicine
Status:	Published
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	No
Item ID:	8507

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Abstract

Diffusivities have been determined for the drug clenbuterol for three non-sink, diffusional problems: diffusion out of a polymer matrix, diffusion through excised, human stratum corneum, and the combined case of diffusion out of a polymer matrix through contiguous, excised stratum corneum. Numerical solution of the diffusion equation for these problems yeilds theoretical values of drug mass in ...