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Measurement of drug diffusivity in stratum corneum membranes and a polyacrylate matrix

URN to cite this document:
urn:nbn:de:bvb:355-epub-85072
DOI to cite this document:
10.5283/epub.8507
Göpferich, Achim ; Lee, Geoffrey
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Date of publication of this fulltext: 05 Aug 2009 13:59


Abstract

Diffusivities have been determined for the drug clenbuterol for three non-sink, diffusional problems: diffusion out of a polymer matrix, diffusion through excised, human stratum corneum, and the combined case of diffusion out of a polymer matrix through contiguous, excised stratum corneum. Numerical solution of the diffusion equation for these problems yeilds theoretical values of drug mass in ...

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