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Determining the solubility and crystal form of clenbuterol in thin films of eudragit NE30D

URN to cite this document:
urn:nbn:de:bvb:355-epub-90140
Göpferich, Achim ; Lee, Geoffrey
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Date of publication of this fulltext: 14 Aug 2009 11:40


Abstract

The solubility of the drug clenbuterol in thin films of surfactant-free Eudragit NE30D has been measured. Light microscopy and differential scanning calorimetry were supplemented by a technique based on measurement of the rate of drug release from the films. The clenbuterol crystals had the form of a fractal, as could be shown by a computer simulation of diffusion-controlled aggregation.


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