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Immunity to MHC class I antigen after direct DNA transfer into skeletal muscle.

Geissler, Edward K., Wang, Jue, Fechner, John H., Burlingham, William J. and Knechtle, Stuart J. (1994) Immunity to MHC class I antigen after direct DNA transfer into skeletal muscle. The Journal of Immunology 152 (2), pp. 413-421.

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Abstract

Plasmid cDNA encoding the alpha-chain of either membrane-bound (pcRT.45) or secreted (pcRQ.B3) RT1Aa MHC class I Ag were transferred to Lewis (RT1(1)) rat skeletal muscle by direct injection. Rats were challenged 7 days later with an ACI (RT1a) heterotropic heart transplant, and cardiac allograft survival, RT1Aa-specific antibody levels, and frequency of ACI-specific CTL were monitored. Graft ...

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Item type:Article
Date:1994
Institutions:Medicine > Lehrstuhl für Chirurgie
Identification Number:
ValueType
8283029PubMed ID
Classification:
NotationType
AnimalsMESH
Base SequenceMESH
DNA Primers/chemistryMESH
Gene Transfer TechniquesMESH
Genes, MHC Class IMESH
Graft SurvivalMESH
Heart Transplantation/immunologyMESH
Histocompatibility Antigens Class I/immunologyMESH
Molecular Sequence DataMESH
MusclesMESH
RatsMESH
Rats, Inbred LewMESH
T-Lymphocytes, Cytotoxic/immunologyMESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:No
Item ID:9554
Owner only: item control page

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