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Adaptive immune responses against parvovirus B19 in patients with myocardial disease.

Lindner, Juha ; Noutsias, Michel ; Lassner, Dirk ; Wenzel, Jürgen ; Schultheiss, Heinz-Peter ; Kuehl, Uwe ; Modrow, Susanne
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Date of publication of this fulltext: 28 Oct 2009 08:31


Abstract

BACKGROUND: Parvovirus B19 (B19V)-DNA is frequently detected in endomyocardial biopsies (EMBs) from patients with acute myocarditis (AMC) and dilated cardiomyopathy (DCM), but also in various healthy tissues. The clinical relevance of this DNA-persistence is unclear. OBJECTIVES: To investigate potential pathogenic influences of B19V-DNA in EMBs, we analyzed B19V-specific adaptive immune responses ...

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