Browse:

The university is member of the Confederation of Open Access Repositories (COAR)

More information about Open Acces at open-acces.net

Untersuchungen zur Stabilität von flavonoid- und gerbstoffhaltigen Drogen

URN to cite this document: urn:nbn:de:bvb:355-opus-2628

Heigl, Dietmar (2003) Untersuchungen zur Stabilität von flavonoid- und gerbstoffhaltigen Drogen. PhD, Universität Regensburg

Preview

Publishing license for publications excluding print on demand
PDF - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
1852Kb

Abstract (German)

In vorliegender Arbeit wurde die Stabilität von Flavonoiden in entsprechenden pflanzlichen Drogen unter Langzeitbedingungen bei 25°C/60% rF und Streßbedingungen bei 40°C/75% rF und bei Temperaturen von 70°C - 100 °C untersucht. Anhand von HPLC-Fingerprintanalysen und photometrischen Methoden wurde das Drogenmaterial untersucht. Bei Gerbstoffdrogen erfolgt die Analyitk mittels photometrischer Methoden und Proteinfällungsmethoden, die auf ihre Eignung für Stabilitsprüfungen untersucht und beurteilt werden sollten.

Translation of the abstract (English)

The aim of the presented work was to examine possible changes in the flavonoid pattern of common flavonoid containing herbal drugs during long term and stress testing periods. HPLC fingerprint was utilized to demonstrate the differences in stability of individual flavonoid components. In addition, the total flavonoid content was determined according to pharmacopoeial photometrical method
Drug material was stored according to the ICH-guidelines at 25 °C and 60 % rh (relative humidity) for long term testing over a 24 months period or at 40°C and 75% rh under stress conditions for 6 months. Increased temperatures were chosen to elucidate possible instabilities of selected flavonoids. As an overall result, during long term testing, no significant changes in the flavonoid pattern can be detected. However, some flavonoid containing herbal drugs (e.g. birch leaves), showed a decrease of most flavonoids when stored at high temperatures by an increase in the respective aglycones. Similar results were obtained during storage at 40°C/75% rh. For tannins, different methods were evaluated for their suitabiliy for stress testing. Photometrical methods like hide powder method, vanillin method, BuOH-method and protein precipitation were object of investigation.

Item Type:	Thesis of the University of Regensburg (PhD)
Referee:	Gerhard (Prof. Dr. ) Franz
Date of exam:	10 June 2003
Institutions:	Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Franz
Keywords:	Flavonoide , Tannine , Umkehrphasen-HPLC , Stabilität , Tannometer , stability testing , flavonoids , tannins , reversed phase
Subjects:	500 Science > 540 Chemistry & allied sciences
Status:	Published
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	Yes
Owner:	Universitätsbibliothek Regensburg
Deposited On:	26 Oct 2009 14:08
Last Modified:	12 Nov 2012 13:10
Item ID:	10105

Export bibliographical data

Literature of the same author

in this repository

at BASE

at Google Scholar

at Scirus

Bookmark

Owner Only: item control page