Deutsch
URN to cite this document: urn:nbn:de:bvb:355-opus-4596
Keck, Christian (2005) Oximether-verbrückte Liganden auf Zuckerbasis in der stereoselektiven Hydrierung von Folsäure. PhD, Universität Regensburg
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Abstract (German)
Neue chirale Liganden wurden dargestellt, indem zur Koordination befähigte Aldehyde und Ketone mit Einfach- und Zweifachzuckern über hydrolysestabile Oximetherbrücken verbunden wurden. Aufgrund ihrer OH-Gruppen sind sie wasserlöslich, während sich ihre acetylierten Analoga in organischen Lösungsmitteln lösen. Die neuen Liganden wurden in homogenen und heterogenisierten Katalysatoren zur stereoselektiven Hydrierung von Folsäure eingesetzt, deren formyliertes Hydrierprodukt das Krebschemotherapeutikum Leucovorin ist.
Translation of the abstract (English)
New chiral ligands were synthesized by combining aldehydes and ketones, able for coordination, with mono- and disaccharides via oxime ether bridges stable towards hydrolysis. Due to their OH groups they were water-soluble, whereas their acetylated analogs dissolved in organic solvents. The new ligands were used in homogeneous and heteregenized catalysts for the stereoselective hydrogenation of folic acid, the formylated hydrogenation product of which is the anticancer drug Leucovorine.
| Item Type: | Thesis of the University of Regensburg (PhD) |
|---|---|
| Referee: | Henri (Prof. Dr.) Brunner |
| Date of exam: | 28 January 2005 |
| Institutions: | Chemistry and Pharmacy > Institut für Anorganische Chemie > Emeriti > Prof. Dr. Henri Brunner |
| Keywords: | Katalytische Hydrierung , Folsäure , Oximether , Ligand , , catalytic hydrogenation , folic acid , oximether , ligand |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Status: | Published |
| Refereed: | Yes, this version has been refereed |
| Created at the University of Regensburg: | Yes |
| Owner: | Universitätsbibliothek Regensburg |
| Deposited On: | 27 Oct 2009 07:58 |
| Last Modified: | 07 Nov 2012 10:53 |
| Item ID: | 10293 |
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