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Synthesis, conformational investigations and applications of alpha-peptides containing cis-beta-aminocyclopropane dicarboxylic acids

URN to cite this document: urn:nbn:de:bvb:355-opus-6446

De Pol, Silvia (2007) Synthesis, conformational investigations and applications of alpha-peptides containing cis-beta-aminocyclopropane dicarboxylic acids. PhD, Universität Regensburg

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Abstract (English)

In this work different alpha-peptides containing two enantiomers of cis-β-amino cyclopropane carboxylic acid (β-ACC) were synthesized in order to extend our knowledge regarding their conformational preferences. Alternated peptides alpha-L-Xaa-β-ACC were synthesized and their conformations were investigated by IR, CD and NMR spectroscopy. Short alpha-L-Ala-β-ACC alternated ...

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Translation of the abstract (German)

Im Rahmen der vorliegenden Arbeit wurden die beiden Enantiomere der cis-β-Amino cyclopropancarbonsäure (β-ACC) in verschiedene Peptide eingebaut und deren Konformation mit Hilfe von IR, CD und NMR Spektroskopie untersucht. Alternierende alpha-Aminosäuren-β-ACC zeigen eine helicale Konformation. Die alternierenden Hepta- und Nonapeptide aus L-Alanin und einem Enantiomer von ...

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Item Type:Thesis of the University of Regensburg (PhD)
Date:9 April 2007
Referee:Oliver (Prof. Dr.) Reiser
Date of exam:16 March 2006
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Oliver Reiser
Keywords:Aminosäureanaloga , Aminosäuren <beta-> , Neuropeptid Y , Konformationsanalyse , RGD-Sequenz , Konformation , Chemische Synthese , Aminocyclopropancarbonsäure , konformativ eingeschränkte Aminosäuren , beta-amino acids , conformationally restricted amino acids , foldamers , neuropeptide Y , RGD
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:27 Oct 2009 08:10
Last Modified:13 Mar 2014 11:43
Item ID:10493
Owner Only: item control page

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