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Die Rolle von p6* für den HI-viralen Replikationszyklus

URN to cite this document: urn:nbn:de:bvb:355-opus-11369

Leiherer, Andreas (2009) Die Rolle von p6* für den HI-viralen Replikationszyklus. PhD, Universität Regensburg

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Abstract (German)

Auf Grund der Genomorganisation von HIV-1 ist das transframe-Protein p6* Bestandteil des Gag-Pol-Polyproteinvorläufers und liegt dort zwischen dem vom gag-Gen kodierten Nukleocapsid-Protein (NC) und der vom pol-Gen kodierten Protease (PR). P6* selbst wird vom 5´Ende des pol-Gens kodiert. Die Translation zweier Polyproteinvorläufer, Gag und Gag-Pol, wird durch einen -1 ribosomalen ...

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Translation of the abstract (English)

The human immunodeficiency virus type 1 (HIV-1) protease (PR) has recently been shown to be inhibited by its propeptide p6* in vitro. P6* also referred to as transframe protein (TFP)-p6pol is located between the nucleocapsid and PR domains in the Gag-Pol polyprotein precursor and is cleaved by the PR during viral maturation. P6* cleavage is absolutely essential to allow complete activation of the ...

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Item Type:Thesis of the University of Regensburg (PhD)
Date:22 January 2009
Referee:Hans Robert (Prof. Dr. Dr.) Kalbitzer
Date of exam:19 December 2008
Institutions:Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Dr. Hans Robert Kalbitzer
Keywords:HIV , Viren , Replikation , Genom , Spacer <Genetik> , Gen nef , Mikrobiologie , Virologie , Offener Leserahmen , Genmutation , p6* , p6pol , Pol , Leseraster , Virusreplikation , Kompetition , p6* , transframe , frameshift , Nef , HIV
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:14 Jan 2010 15:23
Last Modified:13 Mar 2014 12:27
Item ID:12102
Owner Only: item control page

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