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Theoretical study of the interaction of agonists with the 5-HT2A receptor

URN to cite this document: urn:nbn:de:bvb:355-opus-11389

Silva, Maria Elena (2009) Theoretical study of the interaction of agonists with the 5-HT2A receptor. PhD, Universität Regensburg

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Abstract (English)

The 5-HT2A receptor (5-HT2AR) is a biogenic amine receptor that belongs to the class A of G protein coupled receptors. It is characterized by a low affinity for serotonin (5-HT) and for other primary amines. Introduction of an ortho-methoxybenzyl substituent at the amine nitrogen increases the partial agonistic activity by a factor of 40 to 1400 compared with 5-HT. The present study was to ...

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Translation of the abstract (German)

Der 5-HT2A-Rezeptor (5-HT2AR) ist ein Rezeptor für biogene Amine, gehört zur Klasse A der G-Protein gekoppelten Rezeptoren und hat niedrige Affinität für Serotonin (5-HT) und andere primäre Amine. Die Einführung eines ortho-Methoxybenzyl-Substituenten am Amino-Stickstoff steigert die partialagonistische Aktivität um das 40- bis 1400-fache gegenüber 5-HT. Die vorliegende Arbeit sollte die QSAR ...

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Item Type:Thesis of the University of Regensburg (PhD)
Date:24 February 2009
Referee:Stefan (Prof. Dr.) Dove
Date of exam:26 August 2008
Institutions:Chemistry and Pharmacy > Institute of Pharmacy
Keywords:Serotonin , Wirkstoff-Rezeptor-Bindung , Molekulardesign , QSAR , Serotoninrezeptor , 5-HT2A-Rezeptor , G-Protein-gekoppelter Rezeptor , 5-HT2AR-Partialagonist , CoMFA , CoMSIA , 5-HT2A receptor , G protein coupled receptor , 5-HT2A partial agonist , CoMFA , CoMSIA
Subjects:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:14 Jan 2010 15:24
Last Modified:13 Mar 2014 12:28
Item ID:12119
Owner Only: item control page

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