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Effective silencing of EGFR with RNAi demonstrates non-EGFR dependent proliferation of glioma cells

Vollmann, Arabel and Vornlocher, Hans-Peter and Stempfl, Thomas and Brockhoff, Gero and Apfel, Rainer and Bogdahn, Ulrich (2006) Effective silencing of EGFR with RNAi demonstrates non-EGFR dependent proliferation of glioma cells. International journal of oncology 28 (6), pp. 1531-1542.

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Other URL: http://147.52.72.117/IJO/2006/volume28/number6/number6.htm


Abstract

The epidermal growth factor receptor (EGFR, ErbB1) is frequently dysregulated in a variety of solid human tumors, including malignant glioma. EGFR expression has been associated with disease progression, resistance to standard therapies and poor survival. The application of small interfering RNAs (siRNAs) has become an effective and highly specific tool to modulate gene expression, and a wide ...

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Item Type:Article
Date:June 2006
Institutions:Medicine > Zentrum für Hirntumore (ZHT)
Identification Number:
ValueType
16685454PubMed ID
Keywords:AG1478; epidermal growth factor receptor; gene expression analysis; glioma; siRNA
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Ute Lange
Deposited On:23 Mar 2007
Last Modified:13 Mar 2014 12:19
Item ID:1234
Owner Only: item control page

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