Vollmann, Arabel and Vornlocher, Hans-Peter and Stempfl, Thomas and Brockhoff, Gero and Apfel, Rainer and Bogdahn, Ulrich (2006) Effective silencing of EGFR with RNAi demonstrates non-EGFR dependent proliferation of glioma cells. International journal of oncology 28 (6), pp. 1531-1542.
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The epidermal growth factor receptor (EGFR, ErbB1) is frequently dysregulated in a variety of solid human tumors, including malignant glioma. EGFR expression has been associated with disease progression, resistance to standard therapies and poor survival. The application of small interfering RNAs (siRNAs) has become an effective and highly specific tool to modulate gene expression, and a wide ...
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|Institutions:||Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Hirntumore (ZHT)|
|Keywords:||AG1478; epidermal growth factor receptor; gene expression analysis; glioma; siRNA|
|Dewey Decimal Classification:||600 Technology > 610 Medical sciences Medicine|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Unknown|
|Deposited on:||23 Mar 2007|
|Last modified:||13 Mar 2014 12:19|