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(E)-metanicotine hemigalactarate (TC-2403-12) inhibits IL-8 production in cells of the inflamed mucosa

Spoettl, Tanja and Paetzel, Christine and Herfarth, Hans and Bencherif, Merouane and Schoelmerich, Juergen and Greinwald, Roland and Gatto, Gregory J. and Rogler, Gerhard (2007) (E)-metanicotine hemigalactarate (TC-2403-12) inhibits IL-8 production in cells of the inflamed mucosa. International journal of colorectal disease 22 (3), pp. 303-312.

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Other URL: http://dx.doi.org/10.1007/s00384-006-0135-4


Abstract

BACKGROUND: Nicotine is of therapeutic value in ulcerative colitis, but its administration is connected with adverse events. Nicotine derivatives are currently being tested to maintain the therapeutic effects and minimize adverse events. TC-2403-12 is a (E)-metanicotine hemigalactarate. The aim of this study was to determine the effectiveness of TC-2403-12 in the inhibition of TNF- and ...

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Item Type:Article
Date:March 2007
Institutions:Medicine > Lehrstuhl für Innere Medizin I
Medicine > Lehrstuhl für Röntgendiagnostik
Identification Number:
ValueType
10.1007/s00384-006-0135-4DOI
16715250PubMed ID
Keywords:Nicotine derivatives; Ulcerative colitis; Interleukin-8; Mucosal inflammation; Macrophages; Epithelial cells
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Ute Lange
Deposited On:23 Mar 2007
Last Modified:13 Mar 2014 09:47
Item ID:1243
Owner Only: item control page
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