Spoettl, Tanja and Paetzel, Christine and Herfarth, Hans and Bencherif, Merouane and Schoelmerich, Juergen and Greinwald, Roland and Gatto, Gregory J. and Rogler, Gerhard (2007) (E)-metanicotine hemigalactarate (TC-2403-12) inhibits IL-8 production in cells of the inflamed mucosa. International journal of colorectal disease 22 (3), pp. 303-312.
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Other URL: http://dx.doi.org/10.1007/s00384-006-0135-4
BACKGROUND: Nicotine is of therapeutic value in ulcerative colitis, but its administration is connected with adverse events. Nicotine derivatives are currently being tested to maintain the therapeutic effects and minimize adverse events. TC-2403-12 is a (E)-metanicotine hemigalactarate. The aim of this study was to determine the effectiveness of TC-2403-12 in the inhibition of TNF- and ...
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|Institutions:||Medicine > Lehrstuhl für Innere Medizin I|
Medicine > Lehrstuhl für Röntgendiagnostik
|Keywords:||Nicotine derivatives; Ulcerative colitis; Interleukin-8; Mucosal inflammation; Macrophages; Epithelial cells|
|Subjects:||600 Technology > 610 Medical sciences Medicine|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Unknown|
|Deposited On:||23 Mar 2007|
|Last Modified:||13 Mar 2014 09:47|