Anti-interleukin-6 receptor antibody therapy favors adrenal androgen secretion in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled study

DOI zum Zitieren dieses Dokuments:: 10.5283/epub.1246

Straub, Rainer H. ; Härle, Peter ; Yamana, Seizo ; Matsuda, Takemasa ; Takasugi, Kiyoshi ; Kishimoto, Tadamitsu ; Nishimoto, Norihiro

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Veröffentlichungsdatum dieses Volltextes: 05 Aug 2009 13:26

Alternative Links zum Volltext:Pubmed DOI Verlag

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OBJECTIVE: Proinflammatory cytokines such as tumor necrosis factor (TNF) were demonstrated to inhibit adrenal steroidogenesis in patients with rheumatoid arthritis (RA), and this was particularly evident in the increase in adrenal androgen levels during anti-TNF therapy. This study investigated the influence on steroidogenesis of an interleukin-6 (IL-6)-neutralizing strategy using IL-6 receptor ...