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Anti-interleukin-6 receptor antibody therapy favors adrenal androgen secretion in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled study

Straub, Rainer H. and Härle, Peter and Yamana, Seizo and Matsuda, Takemasa and Takasugi, Kiyoshi and Kishimoto, Tadamitsu and Nishimoto, Norihiro (2006) Anti-interleukin-6 receptor antibody therapy favors adrenal androgen secretion in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled study. Arthritis and rheumatism 54 (6), pp. 1778-1785.

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Other URL: http://dx.doi.org/10.1002/art.21826


Abstract

OBJECTIVE: Proinflammatory cytokines such as tumor necrosis factor (TNF) were demonstrated to inhibit adrenal steroidogenesis in patients with rheumatoid arthritis (RA), and this was particularly evident in the increase in adrenal androgen levels during anti-TNF therapy. This study investigated the influence on steroidogenesis of an interleukin-6 (IL-6)-neutralizing strategy using IL-6 receptor ...

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Item Type:Article
Date:June 2006
Institutions:Medicine > Lehrstuhl für Innere Medizin I
Identification Number:
ValueType
16729287PubMed ID
10.1002/art.21826DOI
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Ute Lange
Deposited On:23 Mar 2007
Last Modified:13 Mar 2014 09:47
Item ID:1246
Owner Only: item control page
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