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Bacterial CpG-DNA aggravates immune complex glomerulonephritis: role of TLR9-mediated expression of chemokines and chemokine receptors

Anders, Hans-Joachim and Banas, Bernhard and Linde, Yvonne and Weller, Lars and Cohen, Clemens D and Kretzler, Matthias and Martin, Stefan and Vielhauer, Volker and Schlöndorff, Detlef and Gröne, Hermann-Josef (2003) Bacterial CpG-DNA aggravates immune complex glomerulonephritis: role of TLR9-mediated expression of chemokines and chemokine receptors. Journal of the American Society of Nephrology: JASN 14 (2), pp. 317-326.

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Abstract

Immune complex glomerulonephritis (GN) often deteriorates during infection with viruses and bacteria that, in contrast to mammals, have DNA that contains many unmethylated CpG motifs. Balb/c mice with horse apoferritin-induced GN (HAF-GN) were treated with either saline, CpG-oligodeoxynucleotides (ODN), or control GpC-ODN. Only CpG-ODN exacerbated HAF-GN with an increase of glomerular ...

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Item Type:Article
Date:February 2003
Institutions:Medicine > Lehrstuhl für Innere Medizin II
Identification Number:
ValueType
12538732PubMed ID
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:No
Owner: Petra Gürster
Deposited On:13 Mar 2007
Last Modified:13 Mar 2014 09:48
Item ID:1270
Owner Only: item control page

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