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Chemokine receptor Ccr2 deficiency reduces renal disease and prolongs survival in MRL/lpr lupus-prone mice

de Lema, Guillermo Pérez and Maier, Holger and Franz, Tobias J. and Escribese, Maríia and Chilla, Silvia and Segerer, Stephan and Camarasa, Natalia and Schmid, Holger and Banas, Bernhard and Kalaydjiev, Svetoslav and Busch, Dirk H. and Pfeffer, Klaus and Mampaso, Francisco and Schlöndorff, Detlef and Luckow, Bruno (2005) Chemokine receptor Ccr2 deficiency reduces renal disease and prolongs survival in MRL/lpr lupus-prone mice. Journal of the American Society of Nephrology: JASN 16 (12), pp. 3592-3601.

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Other URL: http://dx.doi.org/10.1681/ASN.2005040426


Abstract

MRL/MpJ-Fas(lpr)/J (MRL/lpr) mice represent a well-established mouse model of human systemic lupus erythematosus. MRL/lpr mice homozygous for the spontaneous lymphoproliferation mutation (lpr) are characterized by systemic autoimmunity, massive lymphadenopathy associated with proliferation of aberrant T cells, splenomegaly, hypergammaglobulinemia, arthritis, and fatal immune complex-mediated ...

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Item Type:Article
Date:December 2005
Institutions:Medicine > Lehrstuhl für Innere Medizin II
Identification Number:
ValueType
16267157PubMed ID
10.1681/ASN.2005040426DOI
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Petra Gürster
Deposited On:20 Mar 2007
Last Modified:13 Mar 2014 09:50
Item ID:1308
Owner Only: item control page
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