Castrop, H. and Oppermann, M. and Weiss, Y. and Huang, Y. and Mizel, D. and Lu, H. and Germain, S. and Schweda, F. and Theilig, F. and Bachmann, S. and Briggs, J. and Kurtz, A. and Schnermann, J. (2006) Reporter gene recombination in juxtaglomerular granular and collecting duct cells by human renin promoter-Cre recombinase transgene. Physiological Genomics 25 (2), pp. 277-285.
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To assess the feasibility of using the renin promoter for expressing Cre recombinase in juxtaglomerular (JG) cells only, we generated five independent transgenic mouse lines (designated hRen-Cre) expressing Cre recombinase under control of a 12.2-kb human renin promoter. In the kidneys of adult mice Cre mRNA (RT-PCR) was found in the renal cortex, with Cre protein (immunohistochemistry) being ...
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|Institutions:||Medicine > Lehrstuhl für Innere Medizin II|
Biology, Preclinical Medicine > Institut für Physiologie
|Keywords:||renin; kidney development|
|Subjects:||500 Science > 570 Life sciences|
600 Technology > 610 Medical sciences Medicine
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Partially|
|Deposited On:||13 Jul 2006|
|Last Modified:||05 Aug 2009 13:22|