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Synthesis and conformational analysis of peptidomimetics containing unnatural amino acids based on a piperazinone and gamma-butyrolactone scaffolds

URN to cite this document: urn:nbn:de:bvb:355-epub-134062

Guitot, Karine (2010) Synthesis and conformational analysis of peptidomimetics containing unnatural amino acids based on a piperazinone and gamma-butyrolactone scaffolds. PhD, Universität Regensburg

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Abstract (English)

The design and synthesis of conformationally restrained amino acids has been the focus of extensive research, because these compounds mimic or induce specific secondary structural features of peptides and proteins. Since the discovery of the crucial role of proline in protein structure, cyclic alpha amino acids containing a heterocyclic ring have attracted considerable attention both from ...

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Translation of the abstract (German)

Das Design und die Synthese konformationell eingeschränkter Aminosäuren ist ein interessantes und viel bearbeitetes Gebiet. Dies begründet sich vor allem darin, das diese Verbindungen bestimmte Sekundärstrukturen in Peptiden und Proteinen imitieren bzw. induzieren können. Seit der Entdeckung der wichtigen Stellung des Prolins in Proteinen sind heterozyklische alpha-Aminosäuren in den Fokus der ...

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Export bibliographical data

Item Type:Thesis of the University of Regensburg (PhD)
Date:25 June 2010
Referee:Prof. Dr. Oliver Reiser
Date of exam:12 December 2008
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Oliver Reiser
Keywords:Peptidomimetika, Foldamere, Solid-Phase Chemie, peptidomimetics, foldamers, solid-phase chemistry
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:25 Jun 2010 13:30
Last Modified:13 Mar 2014 13:24
Item ID:13406
Owner Only: item control page
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