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Disturbance of phospholipid metabolism during the selective destruction of tumor cells induced by alkyl-lysophospholipids

Modolell, M. and Andreesen, Reinhard and Pahlke, W. and Brugger, U. and Munder, P. G. (1979) Disturbance of phospholipid metabolism during the selective destruction of tumor cells induced by alkyl-lysophospholipids. Cancer research 39 (11), pp. 4681-6.

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Abstract

Alkyl-lysophospholipids inhibit the growth of Meth A sarcoma cells in vitro. In contrast, murine bone marrow macrophages are not sensitive to the destructive effect of these substances. Since alkyl-lysophospholipids are antimetabolites in the synthesis of 3-sn-phosphatidylcholine, tumor cell destruction can be correlated with the disturbance of this metabolism. A decreased synthesis of ...

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Item Type:Article
Date:1979
Institutions:Medicine > Abteilung für Hämatologie und Internistische Onkologie
Identification Number:
ValueType
498095PubMed ID
Classification:
NotationType
AnimalsMESH
Cell Survival/drug effectsMESH
Lysophosphatidylcholines/pharmacologyMESH
Lysophospholipase/metabolismMESH
Macrophages/drug effectsMESH
MiceMESH
Mice, Inbred BALB CMESH
Phosphatidylcholines/metabolismMESH
Phospholipids/metabolismMESH
Sarcoma, Experimental/metabolismMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:13 Apr 2010 05:14
Last Modified:13 Apr 2010 05:14
Item ID:14160
Owner Only: item control page
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